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KMID : 0377519810060020225
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 2 p.225 ~ p.232
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Effect of Carnosine on Inflammatory Process and Callus Formation Following Fracture of Bone
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Lee Keun-Young
Kang Sang-Kyoon
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Abstract
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Following the simple bone fracture, the gap between two broken edge is immediately replaced by coagulating blood and tissue fluid, where fibrin mesh is found. Young repairable tissue resembling granulation tissue gradually and growing into the blood clot from periosteum and endosteum, and organized, then forms provisonal callus. Recent studies revealed that carnosine (β-alanyl-histidine) has the promoting effect on wound healing, while other report shows that oxygen consumption of cultured rat fibroblast was increased due to carnosine administration, suggesting rapid fibroblast proliferation under the condition of accelerated cell oxidative-phospholyration. This study was carried out to observe the influence of carnosine on inflammatory reaction and callus formation at the site of bone fracture. Obtained results were as follows: 1. In the early stage of the fracture, repair process was conducted as same that of seen in soft tissue wound healing in the control groups, then provisional callus formation was noted at the fracture site on 14 days of fracture. 2. Inflammatory reaction was more intense and provisional callus formation appears earlier in the carnosine treated groups than that of seen in control groups. 3. It is considered that enhanced inflammatory reaction in the early stage of repair process of carnosine treated group is due to end product of carnosine, which induce abundant granulation tissue formation. Consequently promoted provisional callus formation is possibly caused by accelerated oxidative-phosphorylation of cells.
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